1.
China Journal of Chinese Materia Medica
;
(24): 2143-2145, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-307492
ABSTRACT
<p><b>OBJECTIVE</b>To find out hydrolysis regularity of aconitine.</p><p><b>METHOD</b>Aconitine was air-tighted and hydrolyzed in water for 8, 12, 16, 20, 24 h. The hydrolysis products were analyzed by HPLC-MS. A major hydrolysis product was isolated by alumina oxide column chromatography, and identified by 1H and 13C-NMR spectra.</p><p><b>RESULT</b>HPLC-MS analysis shows that the major hydrolysis products are benzoylaconine and aconine. The hydrolysis can mostly be completed within 20 hours.</p><p><b>CONCLUSION</b>Diester aconitum alkaloid can be changed to monoester aconitum and aconine alkaloids. Under the controled condition benzoylaconine is a major hydrolysis products.</p>